I wrote yesterday about the Twitter stream launched by NIH Director Francis Collins, MD, PhD, to call attention to the real-world effects of the budget sequestration on biological research in labs across the country. Today the agency detailed for the first time the way it plans to carry out the mandatory cuts, including funding fewer new and competing grants and trimming the budget of existing awards. From an article in Science Insider:
As a result, NIH expects to fund 8283 new and competing research grants this year, a drop of 703, according to this table. That number firms up the “hundreds fewer” awards that NIH officials warned of earlier this year. Including ongoing (already awarded) grants that are ending, the total number of research grants will drop by 1357 to 34,902 awards. The decline “reflects the fact that NIH’s budget is being shrunk due to the new budget and political reality, which is bad news for researchers and the patients they are trying to help,” says Tony Mazzaschi of the Association of American Medical Colleges in Washington, D.C.
Individual institutes are also announcing their plans for cuts, the article says.
Here’s a developing social media story of interest to scientists, clinicians and the general public. National Institutes of Health Director Francis Collins, MD, PhD, kicked a hornets’ nest on Twitter earlier today with a tweet asking researchers to describe the direct impact of the U.S. budget sequestration, which began in March, on their research and lives. He asked respondents to use the hashtag #NIHSequesterImpact. The responses (some of which I’ve included below) are fascinating and depressing:
Having a relative with type-1 diabetes makes you 15 times as likely as other people to get the disease, in which the body inappropriately destroys insulin-producing cells in the pancreas. But unlike the more common form of diabetes, type-2 diabetes, physicians don’t know how to prevent type 1 diabetes from developing in at-risk individuals.
To find out, they’re studying family members of type-1 diabetes patients. The large, multi-center research effort, called Type-1 Diabetes TrialNet, screens these folks for the presence of antibodies that recognize “self” tissues and could act as markers of diabetes vulnerability, and invites individuals who have the autoantibodies to take part in diabetes-prevention research. Stanford and Lucile Packard Children’s Hospital are among the 18 clinical centers participating in TrialNet research.
The big news at TrialNet is that, starting today, the first part of the screening process is moving online. Volunteers used to have to participate in a screening event or come to a trial center to be screened, but many people live far from these centers. At the TrialNet screening website, people can now answer a short set of questions to find out if they’re eligible for TrialNet’s research and give consent to participate in screening. After the online questions are complete, eligible volunteers will receive a kit in the mail that they can take to a local lab for a free screening blood test.
Researchers hope this online process will make it easier for more people to participate in type 1 diabetes research. TrialNet must screen more than 20,000 relatives of people with type 1 diabetes each year to reach its scientific goals, according to an National Institutes of Health press release about the new online screening.
There has been a lot of interest in the Stanford studysuggesting that aspirin reduces the risk of melanoma in women; dermatologist Jean Tang, MD, PhD, spent much of her day today discussing the findings with reporters from NPR and the three networks’ evening news programs. Earlier, in a 1:2:1 podcast, Tang talked about her work and described the importance of the Women’s Health Initiative (WHI), from which she and her co-investigators pulled their data:
The Women’s Health Initiative was funded by the National Institutes of Health and American taxpayers’ dollars… This was a huge investment of taxpayers’ dollars, and it has incredibly paid off, [producing] many published papers and, more importantly, many important messages and conclusions about the health of American women.
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Women were enrolled [in the WHI] to reflect the multi-ethnic population of the U.S. So American Indians are represented, Mexican-American women are represented, black women are represented. You are never going to get the richness and diversity of the women represented in this database anywhere else in the world.
DNA may be the main building blocks of the body, but researches are starting to discover that RNA, which transports genetic information within a specific cell, could hold greater potential in understanding a wide range of diseases and developing novel therapeutics.
This recently posted National Institutes of Healthvideo offers a great primer explaining how some RNA, known as extracellular RNAs (exRNA), can travel through bodily fluids and alter cells at a distance. The NIH Common Fund’s Extracellular RNA Communication program is currently investigating how exRNAs control cell behavior. By doing so, researchers hope to develop methods for detecting disease earlier and to create new treatment options, such as harnessing exRNAs’ communication power to turn a diseased cell into a healthy one.
Two years ago, the National Institute on Alcohol Abuse and Alcoholism and American Academy of Pediatrics released a screening tool designed to help clinicians overcome time constraints and other common barriers to youth alcohol screening. But new research shows that many physicians still aren’t discussing alcohol use with their teen patients, resulting in missed opportunities for screening for underage drinking.
In the study, researchers randomly surveyed 2,500 students with an average age of 16 years. Among the participants, 34 percent said they had consumed alcohol in the past month and 26 percent reported binge drinking. However, a significant portion of those who admitted to drinking were not questioned, or counseled, by a doctor, according to an National Institutes of Health release:
“While more than 80 percent of 10th graders said they had seen a doctor in the past year, just 54 percent of that group were asked about drinking, and 40 percent were advised about alcohol harms,” says lead author Ralph W. Hingson, Sc.D., M.P.H., director of NIAAA’s division of epidemiology and prevention research. He adds that, among students who had been seen by a doctor in the past year and who reported drinking in the past month, only 23 percent said they were advised to reduce or stop drinking. The findings are now online in the February issue of Pediatrics.
The researchers also reported that students who said that they had been asked about their drinking were more likely to be advised about alcohol. Nevertheless, among the 43 students who said that they were drunk six times or more in the past month and who said they had been asked about their drinking by a doctor, about 30 percent were not advised about drinking risks, and two-thirds were not advised to reduce or stop drinking.
The findings are notable in light of past research showing that just a two- or three-minute intervention during doctor visits can go a long way in combating underage drinking.
The Connector will keep readers informed of the office’s activities, trainings, educational resources and funding opportunity announcements, as well as podcasts and videos of conversations with engaging behavioral and social sciences. These include:
Dr. Andrea Gielen on “The Science of Injury Prevention Research”
Dr. Charlene Quinn on the promise of mobile health technologies in managing diabetes
Dr. Brian Wansink on “mindless eating,” why we eat more than we think
In addition, the blog include commentaries from Robert Kaplan, PhD, director of the Office of Behavioral and Social Sciences Research. Kaplan plans to explore a range of topics on the blog including mHealth, systems science, dissemination and implementation research and the NIH Toolbox. He also will discuss achieving better population health through improved dissemination of evidence-based interventions.
Rock Talk, a National Institutes of Health (NIH) blog on extramural research policy, debuted two years ago as a way to enhance transparency about how the federal agency develops policies and present data that influence such decisions.
In a commentary published yesterday in Nature, Sally Rockey, PhD, deputy director for extramural research at the NIH, discusses her motivation for launching the blog and how it has increased dialogue with constituents about science policy. She writes:
We learned a lot about our constituents’ interests and needs through the blog, and we have been able to highlight behind-the-scenes data, actively engage the community in policy-making and provide insight into our decisions. Without public input, effective and impactful policy cannot be created. My blogging experience has convinced me that using social-media platforms is one effective way for science-funding agencies to successfully support research.
The blog is not the official vehicle for communicating policy changes. We have the NIH Guide for Grants and Contracts for that. And we have official channels for soliciting public feedback — through requests for information in the NIH Guide, for example. But the blog allows me to extend that conversation to people worldwide, many of whom I would not be able to reach in other ways. People are sometimes concerned that offering a dissenting opinion to NIH officials might affect their chances of getting funding. Although that is absolutely not the case, one advantage the blog does have over some other channels is that it allows people to remain anonymous if they wish.
In addition to fostering conversations on policy, Rockey offers examples of how the blog has allowed her team to provide real-time updates during national emergencies, such as Hurricane Sandy, and debunk urban myths about NIH-supported research.
This video is representative of efficient innate immune reaction in the lymph node, which typically has been studied for the development of adaptive immune response.
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The inguinal lymph node was imaged using a two-photon microscope equipped with an L25.0 x 0.95 water immersion objective. Together, this allowed for the visualization of actual events occurring in challenged lymphatic tissue.
Second place was awarded to a video capturing sperm from two males competing within reproductive tract of a female fruit fly. Footage of a metanephric kidney, cultured in vitro and imaged over four days took third place.
Many of us, myself included, turn to yoga, meditation, tai chi or other mind body practices to reduce stress and relieve anxiety. While past studies provide insights into how these approaches can put us at ease, researchers are still working to understand exactly how such psychosocial interventions can lessen the adverse effects stress on our physical and mental health.
On a related note, the latest Ask Stanford Med Q&A features David Spiegel, MD, director of the Stanford Center for Stress and Health and medical director of the Stanford Center for Integrative Medicine, responding to questions about managing seasonal stress and depression. In the piece, Spiegel discusses the scientific evidence relating to the use of natural remedies, including fish oil and St. John’s wort, in treating holiday stress and depression.
