View Larger
Lucy Shapiro
Academic Appointments
- Professor, Developmental Biology
- Member, Bio-X
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 725-7657 Tel (650) 725-7678Alternate Contact Sergio Alcantara Administrative Support Email Tel Work 650-725-7657
Professional Overview
Administrative Appointments
- Director, Beckman Center for Molecular & Genetic Medicine (2004 - present)
Honors and Awards
- Louisa Gross Horwitz Prize, Columbia University Medical Center (2012)
- Dean's Medal, Stanford University School of Medicine (2012)
- National Medal of Science, National Science Foundation (2011)
- Distinguished Alumna Award, Albert Einstein College of Medicine (2010)
- Abbott Lifetime Achievement Award, ASM (2010)
- John Scott Award, Philadelphia City Trust (2009)
Professional Education
| Ph.D.: | Albert Einstein College of Medicine, Molecular Biology (1966) |
| A.B.: | cum laude, Brooklyn College (1962) |
Postdoctoral Advisees
William Childers, Justin Kern, Keren Lasker, Tao Long, Paola Mera, Jerod Ptacin, Dante Ricci, Jared Schrader
Graduate & Fellowship Program Affiliations
Internet Links
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
A basic question in developmental biology involves the mechanisms used to generate the three-dimensional organization of a cell from a one-dimensional genetic code. Our goal is to define these mechanisms using both molecular genetics and biochemistry. The developmental program by which a single cell proceeds to a fully-developed organism involves cell divisions that yield dissimilar daughter cells. The characteristics that differentiate one daughter cell from the other result from differential transcription and subcellular positioning of regulatory and structural proteins. How this is brought about remains one of the most fundamental questions of developmental biology. To approach this question, we are studying a bacterial cell, whose simple life cycle is focused on the generation of asymmetry in the predivisional cell.
We are using full genome sequence and microarray technology to identify the genetic circuitry that controls the cell cycle in a bacterial cell with 3767 genes. Dynamic protein localization, phosphorelay signaling cascades, and spatially and temporally controlled proteolysis are overlayed on the transcription network that controls cell cycle progression and cell differentiation.
Publications
- Caulobacter chromosome in vivo configuration matches model predictions for a supercoiled polymer in a cell-like confinement. Proc Natl Acad Sci U S A. 2013; (5): 1674-9
- Chromosome architecture is a key element of bacterial cellular organization. Cell Microbiol. 2013; (1): 45-52
- Life in a three-dimensional grid. J Biol Chem. 2012; (45): 38289-94
- Osmolality-dependent relocation of penicillin-binding protein PBP2 to the division site in Caulobacter crescentus. J Bacteriol. 2012; (12): 3116-27
- Structure of the pilus assembly protein TadZ from Eubacterium rectale: implications for polar localization. Mol Microbiol. 2012; (4): 712-27
- Three-dimensional super-resolution imaging of the midplane protein FtsZ in live Caulobacter crescentus cells using astigmatism. Chemphyschem. 2012; (4): 1007-12
Help
Trial Administration