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Harley McAdams
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 858-1864Alternate Contact Sergio Alcantara Administrative support Email Tel Work (650 725-7657
Professional Overview
Honors and Awards
- John Scott Award, John Scott Trust, administrated by City of Philadelphia (2009)
- Fellow, American Academy of Microbiologists (2006)
Professional Education
| PhD: | Rice University, Physics (1967) |
| MA: | Rice University, Physics (1965) |
| MS: | U. Illinois (Urbana), Physics (1962) |
| BS: | Texas A&M, Physics (1960) |
Scientific Focus
Current Research Interests
We are focused on understanding the nature of bacterial genetic regulation. We use a variety of tools: gene expression microarrays, advanced techniques of fluorescence and electron microscopy, and a broad range of computational tools for bioinformatics and modeling.
The aquatic bacterium, Caulobacter crescentus, is our primary model organism. The members of the McAdams group include Electrical Engineers, Physicists, and Physical Chemists who are interested in biologically focused research. We work closely with geneticists and biochemists who are graduate students and postdoctoral fellows in Lucy Shapiro's group to bring a multi-disciplinary approach to the analysis of bacterial regulation and control.
Our interests range far beyond "conventional" approaches to genetic regulation to include the effects of dynamic spatial and temporal positioning of regulatory proteins and the regulatory effects working through the dynamic three-dimensional organization of the chromosome in the dividing cell. We are exploring how regulatory molecules are dynamically localized to particular cell positions and how this localization is integrated into the control mechanisms of the cell.
Publications
- Compaction and transport properties of newly replicated Caulobacter crescentus DNA. Mol Microbiol. 2011; (6): 1349-58
- Direct inference of protein-DNA interactions using compressed sensing methods. Proc Natl Acad Sci U S A. 2011; (36): 14819-24
- The architecture and conservation pattern of whole-cell control circuitry. J Mol Biol. 2011; (1): 28-35
- The essential genome of a bacterium. Mol Syst Biol. 2011: 528
- An essential transcription factor, SciP, enhances robustness of Caulobacter cell cycle regulation. Proc Natl Acad Sci U S A. 2010; (44): 18985-90
- System-level design of bacterial cell cycle control. FEBS Lett. 2009; (24): 3984-91
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