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Frank M. Longo, M.D., Ph.D.
Key Documents
Contact Information
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Clinical Offices
Neurology Department 300 Pasteur Dr H3160 MC 5235 Stanford, CA 94305 Tel Work (650) 723-6469 Fax (650) 725-7459
- Academic Offices
Personal Information Email Tel (650) 724-3172Alternate Contact Diane Madsen Admin Associate Email Tel Work 650-724-3172Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Neurology
- Alzheimer's Disease
- Huntington Disease
Administrative Appointments
- Professor and Chair, Department of Neurology and Neurological Sciences, Stanford University (2006 - present)
- Professor and Chair, Department of Neurology, University of North Carolina, Chapel Hill (2001 - 2005)
- Professor and Vice Chair, UC San Francisco (1999 - 2001)
- Assoc. Chief of Staff for Research and Dev., SF, VAMC (1997 - 2001)
- Assoc. Professor and Vice Chair, UC San Francisco (1996 - 1999)
- Chief, Neurology and Rehab Services, SF, VAMC (1995 - 2001)
Honors and Awards
- Stanford University Fellow, Stanford University (2006-2008)
- Outstanding Alumnus Award, UC San Diego (2000)
- Associate Editor, Annals of Neurology (1994-1997)
- Beeson Award, American Federation for Aging Research (1995)
- Edwin Boldrey Award for Basic Science Research, San Francisco Neurological Society (1990)
- First Place in Neuroscience, National Student Research Forum (1979)
Professional Education
| Board Certification: | Neurology, American Board of Psychiatry and Neurology (1989) |
| Residency: | UCSF Medical Center, CA USA (1987) |
| Internship: | New York VA Medical Center NY (1984) |
| Medical Education: | UC San Diego, CA USA (1981) |
| Ph.D.: | UC San Diego, Neuroscience (1983) |
| M.D.: | UC San Diego, Medicine (1981) |
Graduate & Fellowship Program Affiliations
Internet Links
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
Clinical interests include Alzheimers disease and Huntingtons disease and the development of effective therapeutics for these disorders.
Our research group is focused on the discovery of cellular signaling mechanisms that serve as a basis for the development of novel therapeutic approaches for Alzheimers disease, Huntingtons disease and other neurological disorders. In our Neurotrophin Program, we have pioneered the development of small molecule ligands targeted to neurotrophin receptors to promote novel signaling mechanisms. Small molecule-induced activation of these mechanisms demonstrates therapeutic efficacy in models of Alzheimers disease, Huntingtons disease, Parkinsons disease, spinal cord injury, amyotrophic lateral sclerosis (ALS), HIV dementia and other areas. These novel compounds also promote neurogenesis from stem cells.
In our Protein Tyrosine Phosphatase Receptor Program we have elucidated the role of protein tyrosine phosphatase (PTP) receptors in the nervous system by focusing on LAR, a prototype PTP receptor that we discovered to be expressed in the nervous system. Our studies demonstrated the first CNS and PNS phenotypes in a PTP receptor mutant mouse, discovered PTP extracellular domains responsible for their potent neurite promoting effects, found that LAR associates with Trk neurotrophin receptors to regulate their activity, showed that down regulating LAR promotes stem cell proliferation and stimulates hippocampal neurogenesis, and developed a novel approach for down regulating PTP activity. This work reveals additional candidate therapeutic targets for small molecule development.
Publications
- A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J Neurosci. 2012; (5): 1803-10
- Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke. Stroke. 2012; (7): 1918-24
- Suppression of immunodeficiency virus-associated neural damage by the p75 neurotrophin receptor ligand, LM11A-31, in an in vitro feline model. J Neuroimmune Pharmacol. 2012; (2): 388-400
- Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function. Brain Behav. 2012; (2): 142-54
- Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors. J Neurosci. 2011; (40): 14051-66
- Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest. 2010; (5): 1774-85
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