Publications
-
A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.
Knowles JK,
Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM.
Neurobiol Aging.
2013
-
Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.
Tep C,
Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO.
J Neurosci.
2013;
33
(2):
397-410
-
A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.
Schmid DA,
Yang T, Ogier M, Adams I, Mirakhur Y, Wang Q, Massa SM, Longo FM, Katz DM.
J Neurosci.
2012;
32
(5):
1803-10
-
Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke.
Han J,
Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B, Jing D, Massa SM, Longo FM, Buckwalter MS.
Stroke.
2012;
43
(7):
1918-24
-
Suppression of immunodeficiency virus-associated neural damage by the p75 neurotrophin receptor ligand, LM11A-31, in an in vitro feline model.
Meeker RB,
Poulton W, Feng WH, Hudson L, Longo FM.
J Neuroimmune Pharmacol.
2012;
7
(2):
388-400
-
Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function.
Faizi M,
Bader PL, Saw N, Nguyen TV, Beraki S, Wyss-Coray T, Longo FM, Shamloo M.
Brain Behav.
2012;
2
(2):
142-54
-
Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors.
Fisher D,
Xing B, Dill J, Li H, Hoang HH, Zhao Z, Yang XL, Bachoo R, Cannon S, Longo FM, Sheng M, Silver J, Li S.
J Neurosci.
2011;
31
(40):
14051-66
-
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.
Massa SM,
Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM.
J Clin Invest.
2010;
120
(5):
1774-85
-
The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis.
Bernabeu RO,
Longo FM.
BMC Neurosci.
2010:
11
136
-
Signaling through Rho GTPase pathway as viable drug target.
Lu Q,
Longo FM, Zhou H, Massa SM, Chen YH.
Curr Med Chem.
2009;
16
(11):
1355-65
-
The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.
Knowles JK,
Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM.
J Neurosci.
2009;
29
(34):
10627-37
-
A common motif targets huntingtin and the androgen receptor to the proteasome.
Chandra S,
Shao J, Li JX, Li M, Longo FM, Diamond MI.
J Biol Chem.
2008;
283
(35):
23950-5
-
Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants.
James SE,
Burden H, Burgess R, Xie Y, Yang T, Massa SM, Longo FM, Lu Q.
Neurotoxicology.
2008;
29
(4):
605-12
-
Small molecule modulation of p75 neurotrophin receptor functions.
Longo FM,
Massa SM.
CNS Neurol Disord Drug Targets.
2008;
7
(1):
63-70
-
Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.
Yang T,
Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM.
PLoS One.
2008;
3
(11):
e3604
-
E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner.
Oblander SA,
Ensslen-Craig SE, Longo FM, Brady-Kalnay SM.
Mol Cell Neurosci.
2007;
34
(3):
481-92
-
Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms.
Longo FM,
Yang T, Knowles JK, Xie Y, Moore LA, Massa SM.
Curr Alzheimer Res.
2007;
4
(5):
503-6
-
Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons.
Bernabeu R,
Yang T, Xie Y, Mehta B, Ma SY, Longo FM.
Mol Cell Neurosci.
2006;
31
(4):
723-38
-
LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways.
Yang T,
Massa SM, Longo FM.
J Neurobiol.
2006;
66
(13):
1420-36
-
Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain.
Pehar M,
Cassina P, Vargas MR, Xie Y, Beckman JS, Massa SM, Longo FM, Barbeito L.
Eur J Neurosci.
2006;
24
(6):
1575-80
-
Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function.
Xie Y,
Massa SM, Ensslen-Craig SE, Major DL, Yang T, Tisi MA, Derevyanny VD, Runge WO, Mehta BP, Moore LA, Brady-Kalnay SM, Longo FM.
J Biol Chem.
2006;
281
(24):
16482-92
-
Small molecule approaches for promoting neurogenesis.
Longo FM,
Yang T, Xie Y, Massa SM.
Curr Alzheimer Res.
2006;
3
(1):
5-10
-
Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.
Massa SM,
Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL, Longo FM.
J Neurosci.
2006;
26
(20):
5288-300
-
Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth.
Yang T,
Yin W, Derevyanny VD, Moore LA, Longo FM.
Eur J Neurosci.
2005;
22
(9):
2159-70
-
Neurotrophin Small Molecule Mimetics: Candidate Therapeutic Agents for Neurological Disorders
Longo FM,
Xie Y and Massa SM.
Curr Med Chem - CNS Agents.
2005:
5
29-41
-
Neurotrophin receptor-based strategies for Alzheimer's disease.
Longo FM,
Massa SM.
Curr Alzheimer Res.
2005;
2
(2):
167-9
-
Neuroprotective strategies in Alzheimer's disease.
Longo FM,
Massa SM.
NeuroRx.
2004;
1
(1):
117-27
-
Neurotrophin-based strategies for neuroprotection.
Longo FM,
Massa SM.
J Alzheimers Dis.
2004;
6
(6 Suppl):
S13-7
-
A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs.
Zhang C,
Xie Y, Martignetti JA, Yeo TT, Massa SM, Longo FM.
DNA Cell Biol.
2003;
22
(5):
303-15
-
Alzheimer's therapeutics: neurotrophin domain small molecule mimetics.
Massa SM,
Xie Y, Longo FM.
J Mol Neurosci.
2003;
20
(3):
323-6
-
Leukocyte antigen-related protein tyrosine phosphatase receptor: a small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth.
Yang T,
Bernabeu R, Xie Y, Zhang JS, Massa SM, Rempel HC, Longo FM.
J Neurosci.
2003;
23
(8):
3353-63
-
Alzheimer's therapeutics: neurotrophin small molecule mimetics.
Massa SM,
Xie Y, Longo FM.
J Mol Neurosci.
2002 Aug-Oct;
19
(1-2):
107-11
-
Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.
Buttini M,
Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L.
J Neurosci.
2002;
22
(24):
10539-48
-
ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury.
Beattie MS,
Harrington AW, Lee R, Kim JY, Boyce SL, Longo FM, Bresnahan JC, Hempstead BL, Yoon SO.
Neuron.
2002;
36
(3):
375-86
-
Psychological impact of news of genetic risk for Huntington disease.
Horowitz MJ,
Field NP, Zanko A, Donnelly EF, Epstein C, Longo F.
Am J Med Genet.
2001;
103
(3):
188-92
-
The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo.
Xie Y,
Yeo TT, Zhang C, Yang T, Tisi MA, Massa SM, Longo FM.
J Neurosci.
2001;
21
(14):
5130-8
-
Downregulation of LAR tyrosine phosphatase prevents apoptosis and augments NGF-induced neurite outgrowth.
Tisi MA,
Xie Y, Yeo TT, Longo FM.
J Neurobiol.
2000;
42
(4):
477-86
-
Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma.
Yang T,
Martignetti JA, Massa SM, Longo FM.
Carcinogenesis.
2000;
21
(2):
125-31
-
Nerve growth factor (NGF) loop 4 dimeric mimetics activate ERK and AKT and promote NGF-like neurotrophic effects.
Xie Y,
Tisi MA, Yeo TT, Longo FM.
J Biol Chem.
2000;
275
(38):
29868-74
-
Neurotrophin small-molecule mimetics.
Xie Y,
Longo FM.
Prog Brain Res.
2000:
128
333-47
-
Stress induces zinc finger immediate early genes in the rat adrenal gland.
Honkaniemi J,
Zhang JS, Longo FM, Sharp FR.
Brain Res.
2000;
877
(2):
203-8
-
Electromagnetic fields influence NGF activity and levels following sciatic nerve transection.
Longo FM,
Yang T, Hamilton S, Hyde JF, Walker J, Jennes L, Stach R, Sisken BF.
J Neurosci Res.
1999;
55
(2):
230-7
-
Gene expression along the cerebral-spinal axis after regional gene delivery.
Meuli-Simmen C,
Liu Y, Yeo TT, Liggitt D, Tu G, Yang T, Meuli M, Knauer S, Heath TD, Longo FM, Debs RJ.
Hum Gene Ther.
1999;
10
(16):
2689-700
-
Leukocyte common antigen-related tyrosine phosphatase receptor: increased expression and neuronal-type splicing in breast cancer cells and tissue.
Yang T,
Zhang JS, Massa SM, Han X, Longo FM.
Mol Carcinog.
1999;
25
(2):
139-49
-
LAR Tyrosine Phosphatase Receptor: A Developmental Isoform Is Present in Neurites and Growth Cones and Its Expression Is Regional- and Cell-Specific.
Zhang JS,
Honkaniemi J, Yang T, Yeo TT, Longo FM.
Mol Cell Neurosci.
1998;
10
(5/6):
271-86
-
LAR tyrosine phosphatase receptor: a developmental isoform is present in neurites and growth cones and its expression is regional- and cell-specific.
Zhang JS,
Honkaniemi J, Yang T, Yeo TT, Longo FM.
Mol Cell Neurosci.
1998;
10
(5-6):
271-86
-
LAR tyrosine phosphatase receptor: proximal membrane alternative splicing is coordinated with regional expression and intraneuronal localization.
Honkaniemi J,
Zhang JS, Yang T, Zhang C, Tisi MA, Longo FM.
Brain Res Mol Brain Res.
1998;
60
(1):
1-12
-
Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.
Yeo TT,
Chua-Couzens J, Butcher LL, Bredesen DE, Cooper JD, Valletta JS, Mobley WC, Longo FM.
J Neurosci.
1997;
17
(20):
7594-605
-
Aldose reductase inhibition increases CNTF-like bioactivity and protein in sciatic nerves from galactose-fed and normal rats.
Mizisin AP,
Calcutt NA, DiStefano PS, Acheson A, Longo FM.
Diabetes.
1997;
46
(4):
647-52
-
Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation.
Yeo TT,
Yang T, Massa SM, Zhang JS, Honkaniemi J, Butcher LL, Longo FM.
J Neurosci Res.
1997;
47
(3):
348-60
-
Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism.
Longo FM,
Manthorpe M, Xie YM, Varon S.
J Neurosci Res.
1997;
48
(1):
1-17
-
Minimized hormones grow in stature.
Longo FM,
Mobley WC.
Nat Biotechnol.
1996;
14
(9):
1092
-
Cloning of rat grp75, an hsp70-family member, and its expression in normal and ischemic brain.
Massa SM,
Longo FM, Zuo J, Wang S, Chen J, Sharp FR.
J Neurosci Res.
1995;
40
(6):
807-19
-
LAR tyrosine phosphatase receptor: alternative splicing is preferential to the nervous system, coordinated with cell growth and generates novel isoforms containing extensive CAG repeats.
Zhang JS,
Longo FM.
J Cell Biol.
1995;
128
(3):
415-31
-
Will ciliary neurotrophic factor slow progression of motor neuron disease?
Longo FM,
Ann Neurol.
1994;
36
(2):
125-7
-
Heat shock proteins used to show that haloperidol prevents neuronal injury produced by ketamine, MK801, and phencyclidine.
Sharp FR,
Butman M, Wang S, Koistinaho J, Graham SH, Sagar SM, Berger P, Longo FM.
Ann N Y Acad Sci.
1993:
679
288-90
-
Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia.
Wang S,
Longo FM, Chen J, Butman M, Graham SH, Haglid KG, Sharp FR.
Neurochem Int.
1993;
23
(6):
575-82
-
Leukocyte common antigen-related receptor-linked tyrosine phosphatase. Regulation of mRNA expression.
Longo FM,
Martignetti JA, Le Beau JM, Zhang JS, Barnes JP, Brosius J.
J Biol Chem.
1993;
268
(35):
26503-11
-
Prolonged increases in neurotrophic activity associated with kainate-induced hippocampal synaptic reorganization.
Lowenstein DH,
Seren MS, Longo FM.
Neuroscience.
1993;
56
(3):
597-604
-
cDNA cloning and expression of stress-inducible rat hsp70 in normal and injured rat brain.
Longo FM,
Wang S, Narasimhan P, Zhang JS, Chen J, Massa SM, Sharp FR.
J Neurosci Res.
1993;
36
(3):
325-35
-
Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine.
Sharp FR,
Butman M, Wang S, Koistinaho J, Graham SH, Sagar SM, Noble L, Berger P, Longo FM.
J Neurosci Res.
1992;
33
(4):
605-16
-
Direct sequencing of PCR products using the Maxam-Gilbert method.
Stamm S,
Longo FM.
Genet Anal Tech Appl.
1990;
7
(5):
142-3
-
Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system.
McKinley MP,
Longo FM, Valletta JS, Rahbar F, Neve RL, Prusiner SB, Mobley WC.
Prog Brain Res.
1990:
86
227-38
-
The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides.
Longo FM,
Vu TK, Mobley WC.
Cell Regul.
1990;
1
(2):
189-95
-
Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells.
Knüsel B,
Burton LE, Longo FM, Mobley WC, Koliatsos VE, Price DL, Hefti F.
Exp Neurol.
1990;
110
(3):
274-83
-
Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen.
Mobley WC,
Woo JE, Edwards RH, Riopelle RJ, Longo FM, Weskamp G, Otten U, Valletta JS, Johnston MV.
Neuron.
1989;
3
(5):
655-64
-
Nerve regeneration through artificial tubular implants.
Fields RD,
Le Beau JM, Longo FM, Ellisman MH.
Prog Neurobiol.
1989;
33
(2):
87-134
-
White matter disease in AIDS: findings at MR imaging.
Olsen WL,
Longo FM, Mills CM, Norman D.
Radiology.
1988;
169
(2):
445-8
-
Abnormal nerve regeneration in galactose neuropathy.
Powell HC,
Longo FM, LeBeau JM, Myers RR.
J Neuropathol Exp Neurol.
1986;
45
(2):
151-60
-
Delayed nerve regeneration in streptozotocin diabetic rats.
Longo FM,
Powell HC, Lebeau J, Gerrero MR, Heckman H, Myers RR.
Muscle Nerve.
1986;
9
(5):
385-93
-
Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regeneration chambers.
Longo FM,
Hayman EG, Davis GE, Ruoslahti E, Engvall E, Manthorpe M, Varon S.
Brain Res.
1984;
309
(1):
105-17
-
Neuronotrophic activities in cerebrospinal fluid of head trauma patients.
Longo FM,
Selak I, Zovickian J, Manthorpe M, Varon S, U HS.
Exp Neurol.
1984;
84
(1):
207-18
-
Endogenous and exogenous factors support neuronal survival and choline acetyltransferase activity in embryonic spinal cord cultures.
Manthorpe M,
Luyten W, Longo FM, Varon S.
Brain Res.
1983;
267
(1):
57-66
-
Laminin promotes neuritic regeneration from cultured peripheral and central neurons.
Manthorpe M,
Engvall E, Ruoslahti E, Longo FM, Davis GE, Varon S.
J Cell Biol.
1983;
97
(6):
1882-90
-
Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers.
Longo FM,
Manthorpe M, Skaper SD, Lundborg G, Varon S.
Brain Res.
1983;
261
(1):
109-16
-
Neuronotrophic activity in brain wounds of the developing rat. Correlation with implant survival in the wound cavity.
Manthorpe M,
Nieto-Sampedro M, Skaper SD, Lewis ER, Barbin G, Longo FM, Cotman CW, Varon S.
Brain Res.
1983;
267
(1):
47-56
-
Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: parameters for a bioassay.
Williams LR,
Longo FM, Powell HC, Lundborg G, Varon S.
J Comp Neurol.
1983;
218
(4):
460-70
-
Temporal changes of neuronotrophic activities accumulating in vivo within nerve regeneration chambers.
Longo FM,
Skaper SD, Manthorpe M, Williams LR, Lundborg G, Varon S.
Exp Neurol.
1983;
81
(3):
756-69
-
Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site.
Nieto-Sampedro M,
Lewis ER, Cotman CW, Manthorpe M, Skaper SD, Barbin G, Longo FM, Varon S.
Science.
1982;
217
(4562):
860-1
-
Comparative features of spinal neuronotrophic factors in fluids collected in vitro and in vivo.
Manthorpe M,
Longo FM, Varon S.
J Neurosci Res.
1982;
8
(2-3):
241-50
-
Growth factors and motor neurons.
Varon S,
Manthorpe M, Longo FM.
Adv Neurol.
1982:
36
453-72
-
In vivo regeneration of cut nerves encased in silicone tubes: growth across a six-millimeter gap.
Lundborg G,
Gelberman RH, Longo FM, Powell HC, Varon S.
J Neuropathol Exp Neurol.
1982;
41
(4):
412-22
-
Nerve regeneration across an extended gap: a neurobiological view of nerve repair and the possible involvement of neuronotrophic factors.
Lundborg G,
Dahlin LB, Danielsen N, Hansson HA, Johannesson A, Longo FM, Varon S.
J Hand Surg Am.
1982;
7
(6):
580-7
-
Nerve regeneration in silicone chambers: influence of gap length and of distal stump components.
Lundborg G,
Dahlin LB, Danielsen N, Gelberman RH, Longo FM, Powell HC, Varon S.
Exp Neurol.
1982;
76
(2):
361-75
-
Nerve regeneration model and trophic factors in vivo.
Lundborg G,
Longo FM, Varon S.
Brain Res.
1982;
232
(1):
157-61
-
Spinal cord neuronotrophic factors (SCNTFs): I. Bioassay of schwannoma and other conditioned media.
Longo FM,
Manthorpe M, Varon S.
Brain Res.
1982;
255
(2):
277-94
-
Relation of somal lipid synthesis to the fast axonal transport of protein and lipid.
Longo FM,
Hammerschlag R.
Brain Res.
1980;
193
(2):
471-85
Help