Euan A. Ashley
Academic Appointments
- Assistant Professor - Med Center Line, Medicine - Cardiovascular Medicine
- Member, Child Health Research Institute
Key Documents
Contact Information
-
Clinical Offices
Cardiovascular Medicine 300 Pasteur Dr A265 MC 5319 Stanford, CA 94305 Tel Work (650) 736-7878 Fax (650) 498-7452
- Academic Offices
Personal Information EmailAlternate Contact Terra Coakley Program Manager, Center for Inherited Cardiovascular Disease Email Tel Work 650 498 4900Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Cardiology
- Inherited cardiovascular disease
- Heart Failure
- Genomic medicine
- Hypertrophic Cardiomyopathy
- Cardiomyopathy, Dilated
Administrative Appointments
- Director, Stanford Center for Inherited Cardiovascular Disease (2010 - present)
- Co-Director, Stanford Research Training Program in Myocardial Biology (2010 - present)
- Member, Institute of Medicine Roundtable on Translating Genomic-based Research for Health (2012 - present)
- Director, Stanford Cardiopulmonary Exercise Testing Laboratory (2007 - present)
- Leadership committee, AHA Council on Functional Genomics and Translational Biology (2009 - present)
- Director, Stanford Hypertrophic Cardiomyopathy Center (2006 - present)
Honors and Awards
- NIH Director's New Innovator Award, National Institutes of Health (2009)
- Innovative Research Award, American Heart Association (2008)
- Faculty Scholar, Donald E. and Delia B. Baxter Foundation (2009)
- Career Development Award (K08), National Institutes of Health (2006)
- Western Affiliates Young Investigator Award, American Heart Association (2004)
- Cardiovascular Medicine Basic Science Award, Stanford University (2004)
Professional Education
| Fellowship: | Stanford University Medical Center CA (2006) |
| Fellowship: | University of Oxford, UK (2002) |
| Residency: | University of Oxford, UK (1999) |
| Internship: | University of Glasgow, Scotland, UK (1997) |
| Medical Education: | University of Glasgow, Scotland, UK (1996) |
| DPhil: | University of Oxford, Molecular Cardiology (2002) |
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Community and International Work
Internet Links
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
The Ashley lab is focused on the application of genomics to medicine. More specifically, we develop methods for the interpretation of whole genome sequencing data to improve diagnosis of genetic disease and to personalize the practice of medicine. We are also borderline obsessed with network biology. We study diseased hearts from heart transplants and use RNA sequencing and other tools to derive gene networks and link communities in an attempt to better understand biology. Half of the lab is wet bench so we can easily take advantage of cell systems, transgenic models and microsurgical models of disease to chase down targets and prove causality of our favorite gene targets. Therapeutic development is a near term goal and several of our discoveries are the focus of patents or are being actively pursued by pharmaceutical and biotechnology partners. The group includes grad students, post docs, MDs and genetic counselors. We also lead the Stanford Center for Inherited Cardiovascular Disease.
Clinical Trials
Publications
- APJ acts as a dual receptor in cardiac hypertrophy. Nature. 2012; (7411): 394-8
- Cardiac structural and sarcomere genes associated with cardiomyopathy exhibit marked intolerance of genetic variation. Circ Cardiovasc Genet. 2012; (6): 602-10
- Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy. Biophys J. 2012; (12): 2782-90
- Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012; (6): 1293-307
- Gene coexpression network topology of cardiac development, hypertrophy, and failure. Circ Cardiovasc Genet. 2011; (1): 26-35
- Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet. 2011; (9): e1002280
Help