Publications
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Roles of cadherins and catenins in cell-cell adhesion and epithelial cell polarity.
Nelson WJ,
Dickinson DJ, Weis WI.
Prog Mol Biol Transl Sci.
2013:
116
3-23
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The β-catenin destruction complex.
Stamos JL,
Weis WI.
Cold Spring Harb Perspect Biol.
2013;
5
(1):
a007898
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An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity.
Dickinson DJ,
Nelson WJ, Weis WI.
Bioessays.
2012;
34
(10):
833-40
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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.
Manglik A,
Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S.
Nature.
2012;
485
(7398):
321-6
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E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch.
Borghi N,
Sorokina M, Shcherbakova OG, Weis WI, Pruitt BL, Nelson WJ, Dunn AR.
Proc Natl Acad Sci U S A.
2012;
109
(31):
12568-73
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High-resolution crystal structure of human protease-activated receptor 1.
Zhang C,
Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK.
Nature.
2012;
492
(7429):
387-92
-
N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor.
Zou Y,
Weis WI, Kobilka BK.
PLoS One.
2012;
7
(10):
e46039
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Structure and dynamics of the M3 muscarinic acetylcholine receptor.
Kruse AC,
Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK.
Nature.
2012;
482
(7386):
552-6
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Structure of the δ-opioid receptor bound to naltrindole.
Granier S,
Manglik A, Kruse AC, Kobilka TS, Thian FS, Weis WI, Kobilka BK.
Nature.
2012;
485
(7398):
400-4
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α-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium.
Dickinson DJ,
Robinson DN, Nelson WJ, Weis WI.
Dev Cell.
2012;
23
(3):
533-46
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αE-catenin is an autoinhibited molecule that coactivates vinculin.
Choi HJ,
Pokutta S, Cadwell GW, Bobkov AA, Bankston LA, Liddington RC, Weis WI.
Proc Natl Acad Sci U S A.
2012;
109
(22):
8576-81
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A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins.
Dickinson DJ,
Nelson WJ, Weis WI.
Science.
2011;
331
(6022):
1336-9
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Biochemical and structural characterization of β-catenin interactions with nonphosphorylated and CK2-phosphorylated Lef-1.
Sun J,
Weis WI.
J Mol Biol.
2011;
405
(2):
519-30
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Crystal structure of a rigid four-spectrin-repeat fragment of the human desmoplakin plakin domain.
Choi HJ,
Weis WI.
J Mol Biol.
2011;
409
(5):
800-12
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Crystal structure of the β2 adrenergic receptor-Gs protein complex.
Rasmussen SG,
DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK.
Nature.
2011;
477
(7366):
549-55
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Protein evolution in cell and tissue development: going beyond sequence and transcriptional analysis.
Dickinson DJ,
Weis WI, Nelson WJ.
Dev Cell.
2011;
21
(1):
32-4
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Structural basis for langerin recognition of diverse pathogen and mammalian glycans through a single binding site.
Feinberg H,
Taylor ME, Razi N, McBride R, Knirel YA, Graham SA, Drickamer K, Weis WI.
J Mol Biol.
2011;
405
(4):
1027-39
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Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.
Ahn VE,
Chu ML, Choi HJ, Tran D, Abo A, Weis WI.
Dev Cell.
2011;
21
(5):
862-73
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Structure and function of an irreversible agonist-β(2) adrenoceptor complex.
Rosenbaum DM,
Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK.
Nature.
2011;
469
(7329):
236-40
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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.
Rasmussen SG,
Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, Steyaert J, Weis WI, Kobilka BK.
Nature.
2011;
469
(7329):
175-80
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The beta-catenin binding protein ICAT modulates androgen receptor activity.
Zhuo M,
Zhu C, Sun J, Weis WI, Sun Z.
Mol Endocrinol.
2011;
25
(10):
1677-88
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AlphaE-catenin regulates actin dynamics independently of cadherin-mediated cell-cell adhesion.
Benjamin JM,
Kwiatkowski AV, Yang C, Korobova F, Pokutta S, Svitkina T, Weis WI, Nelson WJ.
J Cell Biol.
2010;
189
(2):
339-52
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In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans.
Kwiatkowski AV,
Maiden SL, Pokutta S, Choi HJ, Benjamin JM, Lynch AM, Nelson WJ, Weis WI, Hardin J.
Proc Natl Acad Sci U S A.
2010;
107
(33):
14591-6
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Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.
Bokoch MP,
Zou Y, Rasmussen SG, Liu CW, Nygaard R, Rosenbaum DM, Fung JJ, Choi HJ, Thian FS, Kobilka TS, Puglisi JD, Weis WI, Pardo L, Prosser RS, Mueller L, Kobilka BK.
Nature.
2010;
463
(7277):
108-12
-
Trimeric structure of langerin.
Feinberg H,
Powlesland AS, Taylor ME, Weis WI.
J Biol Chem.
2010;
285
(17):
13285-93
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Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes.
Choi HJ,
Gross JC, Pokutta S, Weis WI.
J Biol Chem.
2009;
284
(46):
31776-88
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Segmented helical structure of the neck region of the glycan-binding receptor DC-SIGNR.
Feinberg H,
Tso CK, Taylor ME, Drickamer K, Weis WI.
J Mol Biol.
2009;
394
(4):
613-20
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The first propeller domain of LRP6 regulates sensitivity to DKK1.
Binnerts ME,
Tomasevic N, Bright JM, Leung J, Ahn VE, Kim KA, Zhan X, Liu S, Yonkovich S, Williams J, Zhou M, Gros D, Dixon M, Korver W, Weis WI, Abo A.
Mol Biol Cell.
2009;
20
(15):
3552-60
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Biochemical and structural analysis of alpha-catenin in cell-cell contacts.
Pokutta S,
Drees F, Yamada S, Nelson WJ, Weis WI.
Biochem Soc Trans.
2008;
36
(Pt 2):
141-7
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Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change.
Davies JM,
Brunger AT, Weis WI.
Structure.
2008;
16
(5):
715-26
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Structural insights into G-protein-coupled receptor activation.
Weis WI,
Kobilka BK.
Curr Opin Struct Biol.
2008;
18
(6):
734-40
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A monoclonal antibody for G protein-coupled receptor crystallography.
Day PW,
Rasmussen SG, Parnot C, Fung JJ, Masood A, Kobilka TS, Yao XJ, Choi HJ, Weis WI, Rohrer DK, Kobilka BK.
Nat Methods.
2007;
4
(11):
927-9
-
Catenins: playing both sides of the synapse.
Kwiatkowski AV,
Weis WI, Nelson WJ.
Curr Opin Cell Biol.
2007;
19
(5):
551-6
-
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
Rasmussen SG,
Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK.
Nature.
2007;
450
(7168):
383-7
-
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function.
Rosenbaum DM,
Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK.
Science.
2007;
318
(5854):
1266-73
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Cherezov V,
Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC.
Science.
2007;
318
(5854):
1258-65
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Multiple modes of binding enhance the affinity of DC-SIGN for high mannose N-linked glycans found on viral glycoproteins.
Feinberg H,
Castelli R, Drickamer K, Seeberger PH, Weis WI.
J Biol Chem.
2007;
282
(6):
4202-9
-
Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism.
Feinberg H,
Taylor ME, Weis WI.
J Biol Chem.
2007;
282
(23):
17250-8
-
Structure and mechanism of cadherins and catenins in cell-cell contacts.
Pokutta S,
Weis WI.
Annu Rev Cell Dev Biol.
2007:
23
237-61
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Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism.
Hattendorf DA,
Andreeva A, Gangar A, Brennwald PJ, Weis WI.
Nature.
2007;
446
(7135):
567-71
-
Crystal structure of the S.cerevisiae exocyst component Exo70p.
Hamburger ZA,
Hamburger AE, West AP, Weis WI.
J Mol Biol.
2006;
356
(1):
9-21
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Re-solving the cadherin-catenin-actin conundrum.
Weis WI,
Nelson WJ.
J Biol Chem.
2006;
281
(47):
35593-7
-
Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity.
Choi HJ,
Huber AH, Weis WI.
J Biol Chem.
2006;
281
(2):
1027-38
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Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.
Drees F,
Pokutta S, Yamada S, Nelson WJ, Weis WI.
Cell.
2005;
123
(5):
903-15
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Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation.
Daniels DL,
Weis WI.
Nat Struct Mol Biol.
2005;
12
(4):
364-71
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Conformational changes of p97 during nucleotide hydrolysis determined by small-angle X-Ray scattering.
Davies JM,
Tsuruta H, May AP, Weis WI.
Structure.
2005;
13
(2):
183-95
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Deconstructing the cadherin-catenin-actin complex.
Yamada S,
Pokutta S, Drees F, Weis WI, Nelson WJ.
Cell.
2005;
123
(5):
889-901
-
Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR.
Feinberg H,
Guo Y, Mitchell DA, Drickamer K, Weis WI.
J Biol Chem.
2005;
280
(2):
1327-35
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Structure of the armadillo repeat domain of plakophilin 1.
Choi HJ,
Weis WI.
J Mol Biol.
2005;
346
(1):
367-76
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In vitro methods for investigating desmoplakin-intermediate filament interactions and their role in adhesive strength.
Hudson TY,
Fontao L, Godsel LM, Choi HJ, Huen AC, Borradori L, Weis WI, Green KJ.
Methods Cell Biol.
2004:
78
757-86
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Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.
Ha NC,
Tonozuka T, Stamos JL, Choi HJ, Weis WI.
Mol Cell.
2004;
15
(4):
511-21
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Structural aspects of adherens junctions and desmosomes.
Choi HJ,
Weis WI.
Handb Exp Pharmacol.
2004;
(165):
23-52
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Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR.
Guo Y,
Feinberg H, Conroy E, Mitchell DA, Alvarez R, Blixt O, Taylor ME, Weis WI, Drickamer K.
Nat Struct Mol Biol.
2004;
11
(7):
591-8
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Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2.
Feinberg H,
Uitdehaag JC, Davies JM, Wallis R, Drickamer K, Weis WI.
EMBO J.
2003;
22
(10):
2348-59
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Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin.
Pokutta S,
Drees F, Takai Y, Nelson WJ, Weis WI.
J Biol Chem.
2002;
277
(21):
18868-74
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Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle.
Rouiller I,
DeLaBarre B, May AP, Weis WI, Brunger AT, Milligan RA, Wilson-Kubalek EM.
Nat Struct Biol.
2002;
9
(12):
950-7
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ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules.
Daniels DL,
Weis WI.
Mol Cell.
2002;
10
(3):
573-84
-
Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition.
Ng KK,
Kolatkar AR, Park-Snyder S, Feinberg H, Clark DA, Drickamer K, Weis WI.
J Biol Chem.
2002;
277
(18):
16088-95
-
Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure.
Choi HJ,
Park-Snyder S, Pascoe LT, Green KJ, Weis WI.
Nat Struct Biol.
2002;
9
(8):
612-20
-
The cytoplasmic face of cell contact sites.
Pokutta S,
Weis WI.
Curr Opin Struct Biol.
2002;
12
(2):
255-62
-
Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog.
Misura KM,
Bock JB, Gonzalez LC, Scheller RH, Weis WI.
Proc Natl Acad Sci U S A.
2002;
99
(14):
9184-9
-
A novel snare N-terminal domain revealed by the crystal structure of Sec22b.
Gonzalez LC,
Weis WI, Scheller RH.
J Biol Chem.
2001;
276
(26):
24203-11
-
Crystal structure and biophysical properties of a complex between the N-terminal SNARE region of SNAP25 and syntaxin 1a.
Misura KM,
Gonzalez LC, May AP, Scheller RH, Weis WI.
J Biol Chem.
2001;
276
(44):
41301-9
-
Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex.
Eklof Spink K,
Fridman SG, Weis WI.
EMBO J.
2001;
20
(22):
6203-12
-
Self-association of the H3 region of syntaxin 1A. Implications for intermediates in SNARE complex assembly.
Misura KM,
Scheller RH, Weis WI.
J Biol Chem.
2001;
276
(16):
13273-82
-
Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.
Feinberg H,
Mitchell DA, Drickamer K, Weis WI.
Science.
2001;
294
(5549):
2163-6
-
The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover.
Huber AH,
Stewart DB, Laurents DV, Nelson WJ, Weis WI.
J Biol Chem.
2001;
276
(15):
12301-9
-
The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.
Huber AH,
Weis WI.
Cell.
2001;
105
(3):
391-402
-
Unraveling the mechanism of the vesicle transport ATPase NSF, the N-ethylmaleimide-sensitive factor.
May AP,
Whiteheart SW, Weis WI.
J Biol Chem.
2001;
276
(25):
21991-4
-
beta-catenin: molecular plasticity and drug design.
Daniels DL,
Eklof Spink K, Weis WI.
Trends Biochem Sci.
2001;
26
(11):
672-8
-
Mechanism of pH-dependent N-acetylgalactosamine binding by a functional mimic of the hepatocyte asialoglycoprotein receptor.
Feinberg H,
Torgersen D, Drickamer K, Weis WI.
J Biol Chem.
2000;
275
(45):
35176-84
-
Protein-protein interactions in intracellular membrane fusion.
Misura KM,
May AP, Weis WI.
Curr Opin Struct Biol.
2000;
10
(6):
662-71
-
Structural basis of the Axin-adenomatous polyposis coli interaction.
Spink KE,
Polakis P, Weis WI.
EMBO J.
2000;
19
(10):
2270-9
-
Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor.
Feinberg H,
Park-Snyder S, Kolatkar AR, Heise CT, Taylor ME, Weis WI.
J Biol Chem.
2000;
275
(28):
21539-48
-
Structure of the dimerization and beta-catenin-binding region of alpha-catenin.
Pokutta S,
Weis WI.
Mol Cell.
2000;
5
(3):
533-43
-
Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex.
Misura KM,
Scheller RH, Weis WI.
Nature.
2000;
404
(6776):
355-62
-
Crystal structure of the amino-terminal domain of N-ethylmaleimide-sensitive fusion protein.
May AP,
Misura KM, Whiteheart SW, Weis WI.
Nat Cell Biol.
1999;
1
(3):
175-82
-
Ca2+-dependent structural changes in C-type mannose-binding proteins.
Ng KK,
Park-Snyder S, Weis WI.
Biochemistry.
1998;
37
(51):
17965-76
-
Coupling of prolyl peptide bond isomerization and Ca2+ binding in a C-type mannose-binding protein.
Ng KK,
Weis WI.
Biochemistry.
1998;
37
(51):
17977-89
-
Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein.
Lenzen CU,
Steinmann D, Whiteheart SW, Weis WI.
Cell.
1998;
94
(4):
525-36
-
Mechanism of N-acetylgalactosamine binding to a C-type animal lectin carbohydrate-recognition domain.
Kolatkar AR,
Leung AK, Isecke R, Brossmer R, Drickamer K, Weis WI.
J Biol Chem.
1998;
273
(31):
19502-8
-
The C-type lectin superfamily in the immune system.
Weis WI,
Taylor ME, Drickamer K.
Immunol Rev.
1998:
163
19-34
-
Cell-surface carbohydrate recognition by animal and viral lectins.
Weis WI,
Curr Opin Struct Biol.
1997;
7
(5):
624-30
-
Structure of a selectin-like mutant of mannose-binding protein complexed with sialylated and sulfated Lewis(x) oligosaccharides.
Ng KK,
Weis WI.
Biochemistry.
1997;
36
(5):
979-88
-
Three-dimensional structure of the armadillo repeat region of beta-catenin.
Huber AH,
Nelson WJ, Weis WI.
Cell.
1997;
90
(5):
871-82
-
Direct observation of protein solvation and discrete disorder with experimental crystallographic phases.
Burling FT,
Weis WI, Flaherty KM, Brünger AT.
Science.
1996;
271
(5245):
72-7
-
Structural analysis of monosaccharide recognition by rat liver mannose-binding protein.
Ng KK,
Drickamer K, Weis WI.
J Biol Chem.
1996;
271
(2):
663-74
-
Structural basis of galactose recognition by C-type animal lectins.
Kolatkar AR,
Weis WI.
J Biol Chem.
1996;
271
(12):
6679-85
-
Structural basis of lectin-carbohydrate recognition.
Weis WI,
Drickamer K.
Annu Rev Biochem.
1996:
65
441-73
-
Binding of sugar ligands to Ca(2+)-dependent animal lectins. I. Analysis of mannose binding by site-directed mutagenesis and NMR.
Iobst ST,
Wormald MR, Weis WI, Dwek RA, Drickamer K.
J Biol Chem.
1994;
269
(22):
15505-11
-
Trimeric structure of a C-type mannose-binding protein.
Weis WI,
Drickamer K.
Structure.
1994;
2
(12):
1227-40
-
Molecular mechanisms of complex carbohydrate recognition at the cell surface.
Weis WI,
Quesenberry MS, Taylor ME, Bezouska K, Hendrickson WA, Drickamer K.
Cold Spring Harb Symp Quant Biol.
1992:
57
281-9
-
Structure of a C-type mannose-binding protein complexed with an oligosaccharide.
Weis WI,
Drickamer K, Hendrickson WA.
Nature.
1992;
360
(6400):
127-34
-
Physical characterization and crystallization of the carbohydrate-recognition domain of a mannose-binding protein from rat.
Weis WI,
Crichlow GV, Murthy HM, Hendrickson WA, Drickamer K.
J Biol Chem.
1991;
266
(31):
20678-86
-
Rigid protein motion as a model for crystallographic temperature factors.
Kuriyan J,
Weis WI.
Proc Natl Acad Sci U S A.
1991;
88
(7):
2773-7
-
Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by MAD phasing.
Weis WI,
Kahn R, Fourme R, Drickamer K, Hendrickson WA.
Science.
1991;
254
(5038):
1608-15
-
Refinement of the influenza virus hemagglutinin by simulated annealing.
Weis WI,
Brünger AT, Skehel JJ, Wiley DC.
J Mol Biol.
1990;
212
(4):
737-61
-
The structure of a membrane fusion mutant of the influenza virus haemagglutinin.
Weis WI,
Cusack SC, Brown JH, Daniels RS, Skehel JJ, Wiley DC.
EMBO J.
1990;
9
(1):
17-24
-
Conformational aspects of the acid-induced fusion mechanism of influenza virus hemagglutinin. Circular dichroism and fluorescence studies.
Wharton SA,
Ruigrok RW, Martin SR, Skehel JJ, Bayley PM, Weis W, Wiley DC.
J Biol Chem.
1988;
263
(9):
4474-80
-
Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid.
Weis W,
Brown JH, Cusack S, Paulson JC, Skehel JJ, Wiley DC.
Nature.
1988;
333
(6172):
426-31
-
Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion.
Ruigrok RW,
Aitken A, Calder LJ, Martin SR, Skehel JJ, Wharton SA, Weis W, Wiley DC.
J Gen Virol.
1988:
69 ( Pt 11)
2785-95
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