Lucy Shapiro
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 725-7657 Tel (650) 725-7678Alternate Contact Sergio Alcantara Administrative Support Email Tel Work 650-725-7657
Professional Overview
Administrative Appointments
- Director, Beckman Center for Molecular & Gentic Medicine (2004 - present)
Honors and Awards
- Elected to the American Philosophical Society, American Philosophical Society (2003)
- Selman A. Waksman Award, National Academy of Sciences (2005)
- Hitchcock Professorship, UC Berkeley (2008)
- Address the Swedish Royal Academy of Sciences, Swedish (2008)
- Gairdner Award, Gairdner Foundation (2009)
- John Scott Award, Philadelphia City Trust (2009)
Professional Education
| Ph.D.: | Albert Einstein College of Medicine, Molecular Biology (1966) |
| A.B.: | cum laude, Brooklyn College (1962) |
Postdoctoral Advisees
Rene Chan, William Childers, Justin Kern, Tao Long, Paola Mera, Khanh Ngo, Jerod Ptacin, Elif Sarinay Cenik, Jared Schrader
Graduate & Fellowship Program Affiliations
Internet Links
Industry Relationships
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Scientific Focus
Current Research Interests
A basic question in developmental biology involves the mechanisms used to generate the three-dimensional organization of a cell from a one-dimensional genetic code. Our goal is to define these mechanisms using both molecular genetics and biochemistry. The developmental program by which a single cell proceeds to a fully-developed organism involves cell divisions that yield dissimilar daughter cells. The characteristics that differentiate one daughter cell from the other result from differential transcription and subcellular positioning of regulatory and structural proteins. How this is brought about remains one of the most fundamental questions of developmental biology. To approach this question, we are studying a bacterial cell, whose simple life cycle is focused on the generation of asymmetry in the predivisional cell.
We are using full genome sequence and microarray technology to identify the genetic circuitry that controls the cell cycle in a bacterial cell with 3767 genes. Dynamic protein localization, phosphorelay signaling cascades, and spatially and temporally controlled proteolysis are overlayed on the transcription network that controls cell cycle progression and cell differentiation.
Publications
- An SMC ATPase mutant disrupts chromosome segregation in Caulobacter. Mol Microbiol. 2011; (6): 1359-74
- Assembly of the Caulobacter cell division machine. Mol Microbiol. 2011; (6): 1680-98
- Bacterial polarity. Curr Opin Cell Biol. 2011; (1): 71-7
- Mutations in the nucleotide binding pocket of MreB can alter cell curvature and polar morphology in Caulobacter. Mol Microbiol. 2011; (2): 368-94
- Regulatory response to carbon starvation in Caulobacter crescentus. PLoS One. 2011; (4): e18179
- The architecture and conservation pattern of whole-cell control circuitry. J Mol Biol. 2011; (1): 28-35
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