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Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.

Open to first year Department of Genetics and Developmental Biology students, to others with consent of instructors. Introduction to basic manipulations, both experimental and conceptual, in genetics and developmental biology.

Utilizes lectures and small group discussions to develop a working knowlege of human genetics as applicable to clinical medicine and research. Basic principles of inheritance, risk assessment, and population genetics, illustrated by using clinical examples drawn from diverse areas of medical genetics practice including prenatal, pediatric, adult and cancer genetics. Practical aspects of molecular and cytogenetic diagnostic methods emphasized. Existing and emerging treatment strategies for single gene disorders also covered. Prerequisites: biochemistry; basic genetics.

Topics: introduction to bioinformatics and computational biology, algorithms for alignment of biological sequences and structures, computing with strings, phylogenetic tree construction, hidden Markov models, Gibbs Sampling, basic structural computations on proteins, protein structure prediction, protein threading techniques, homology modeling, molecular dynamics and energy minimization, statistical analysis of 3D biological data, integration of data sources, knowledge representation and controlled terminologies for molecular biology, microarray analysis, machine learning (clustering and classification), and natural language text processing. Prerequisites: programming skills; consent of instructor for 3 units.

Literature discussion in conjunction with the Frontiers in Biological Research seminar series in which investigators present current work. Students and faculty meet beforehand to discuss papers from the speaker's primary research literature. Students meet with the speaker after the seminar to discuss their research and future direction, commonly used techniques to study problems in biology, and comparison between the genetic and biochemical approaches in biological research.

Genetics graduate student lab research from first quarter to filing of candidacy. Prerequisite: consent of instructor.

For genetic counseling students, graduate students in genetics, medical students, residents, and postdoctoral fellows interested in the practice of medical genetics. Gene structure and function; the impact of mutation and polymorphism as they relate to developmental pathways and health and human disease; population based genetics; approaches to the study of complex genetic conditions; GWAS and genome sequencing technologies; variant curation; gene therapy, proteomics, stem cell biology, and pharmacogenetics. Undergraduates require consent of instructor and a basic genetics course.

For genetic counseling students, graduate students in human genetics, medical students, residents, and fellows; undergraduates with consent of instructor. Principles of medical genetics including taking a family history, modes of inheritance, and mathematical principles of medical genetics (Bayes theorem, population genetics). An additional problem set is required for 3 units.

For genetic counseling students, medical students, residents, and fellows. Uses a combination of case based assignments and online didactic lectures to introduce the laboratory concepts of cytogenetics, molecular genetics and biochemical genetics, and to illustrate common genetic conditions that are diagnosed through such testing, introducing students to skills in case preparation, management and presentation.